Article

Chromatin regulates genome-wide transcription factor binding affinities

2022-04-05

Abstract excerpt

Transcription factor binding across the genome is regulated by DNA sequence and chromatin features. However, it is not yet possible to quantify the impact of chromatin context on genome-wide transcription factor binding affinities. Here we report the establishment of a method to determine genome-wide absolute apparent binding affinities of transcription factors to native, chromatinized DNA. Our experiments reveale...

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Literature Corpus work: c8fce030-4e32-5d93-acf8-74c0c4b93ac6
DOI: 10.1101/2022.04.04.486948

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