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Intrinsic DNA codes govern distinct modes of nucleosome-transcription factor interactions

2025-12-30

Abstract excerpt

The interplay between transcription factors (TFs) and nucleosomes is central to gene regulation, yet most studies adopt a protein-centric perspective that largely overlooks DNA sequence contributions. Here, we identify four distinct nucleosomal DNA classes, including the canonical WW/SS pattern (W = A/T, S = G/C). All four nucleosome types are widespread across the human genome both in vivo and in vitro . Nucleo...

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Literature Corpus work
8750c346-e6fd-5c4a-ba2e-27ed89196178
DOI
10.64898/2025.12.30.697010
Open publication

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Intrinsic DNA codes govern distinct modes of nucleosome-transcription factor interactionsDOI 10.64898/2025.12.30.697010
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