Article

ChromWave: Deciphering the DNA-encoded competition between transcription factors and nucleosomes with deep neural networks

2021-03-20

Abstract excerpt

<h4>Summary</h4> Transcription factors (TFs) regulate gene expression by recognising and binding specific DNA sequences. At times, these regulatory elements may be occluded by nucleosomes, making them inaccessible for TF-binding. The competition for DNA occupancy between TFs and nucleosomes, and associated gene regulatory outputs, are important consequences of the cis-regulatory information encoded in the genome....

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Literature Corpus work: 668f1368-ceab-58a1-a978-b1909cb61cc6
DOI: 10.1101/2021.03.19.436198

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