Article

Nucleosome Engagement Regulates RORγt Structure and Dynamics

2025-03-12

Abstract excerpt

<h4>ABSTRACT</h4> The retinoic acid-related orphan receptor gamma (RORγt) acts as the major transcriptional activator in Th17 cell development and function to mediate adaptive immune defenses against pathogenic infection. RORγt engages accessible DNA response elements in the genome and interplays with coactivator proteins and accessory transcription factors to drive gene expression. However, how the chromatin env...

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Literature Corpus work: e4a9b841-b37c-5280-a85d-39a727f63e49
DOI: 10.1101/2025.03.10.642251

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