Article

Enhancer-driven local 3D chromatin domain folding modulates transcription in human mammary tumor cells

2023-10-19

Abstract excerpt

The genome is organized in functional compartments and structural domains at the sub-megabase scale. How within these domains interactions between numerous cis-acting enhancers and promoters regulate transcription remains an open question. Here, we determined chromatin folding and composition over several hundred kb around estrogen responsive genes in human breast cancer cell lines following hormone stimulation. M...

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Literature Corpus work: 87006fd6-e6c6-52f0-b94b-ef5de9779eec
DOI: 10.1101/2023.10.17.562690

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