Article

Mechanistic insights into chromatin modulation by the “orphan” remodeler ATRX

2026-01-05

Abstract excerpt

Alpha-thalassemia/mental retardation syndrome X-linked protein (ATRX) is an ATP-dependent chromatin remodeler that performs diverse functions, including spacing nucleosomes, facilitating the deposition of histone variant H3.3, and preventing replication stress. The mechanism by which ATRX modulates chromatin is unknown. Here, our cryo-EM structure revealed that ATRX recognizes and modulates the nucleosome through...

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Literature Corpus work: bbf99f36-c2d1-5dcf-8341-3ae149a3fa26
DOI: 10.64898/2026.01.04.697590

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