Article

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement

2021-05-26

Abstract excerpt

<h4>ABSTRACT</h4> The retinoic acid receptor-related orphan receptor γ (RORγ) is a ligand-dependent transcription factor of the nuclear receptor super family that underpins metabolic activity, immune function, and cancer progression. Despite being a valuable drug target in health and disease, our understanding of the ligand-dependent activities of RORγ is far from complete. Like most nuclear receptors, RORγ must...

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Literature Corpus work: 1b3981ac-36c7-56ea-a02f-2492050f83ec
DOI: 10.1101/2021.05.25.445650

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