Article

DNA flexibility regulates transcription factor binding to nucleosomes

2024-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Cell fate decisions are controlled by sequence-specific transcription factors (TFs), referred to as ‘pioneer’ factors, that bind their target sites within nucleosomes (’pioneer binding’) and thus initiate chromatin opening. However, pioneers bind just a minority of their recognition sequences present in the genome, suggesting that local sequence context features may regulate pioneer binding. Her...

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Literature Corpus work: 3c21f7dc-e536-55e8-b9ef-2ad179fefa9c
DOI: 10.1101/2024.09.02.610559

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