Structural Insights Into Thyroid Hormone Receptors

doi:10.1210/endocr/bqae154

Article

Structural Insights Into Thyroid Hormone Receptors

14 Nov 2024

Abstract excerpt

Thyroid hormone receptors (TRs) are essential components of the endocrine system, mediating the cellular effects of thyroid hormones. The 2 TR genes, THRA and THRB, encode 4 isoforms, with TRα1 and TRβ1 being the most prevalent. TRs are ligand-dependent transcription factors and members of the nuclear receptor superfamily, indispensable for human growth, development, and metabolism. Dysfunctional TR signaling can...

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