Article

Intragenic recruitment of NF-κB drives alternative splicing modifications upon activation by the viral oncogene TAX of HTLV-1

2019-06-20

Abstract excerpt

<h4>Summary</h4> The chronic NF-κB activation in inflammation and cancer has long been linked to persistent activation of NF-κB responsive gene promoters. However, NF-κB factors such as RELA also massively bind to gene bodies. Here, we demonstrate that the recruitment of RELA to intragenic regions regulates alternative splicing upon activation of NF-κB by the viral oncogene TAX of HTLV-1. Integrative analysis of...

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Literature Corpus work: 8b72bf1e-e14b-5e39-a529-bbae358165cd
DOI: 10.1101/676353

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