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Article

A proximal enhancer regulates RORA expression during early human Th17 cell differentiation.

Clinical immunology (Orlando, Fla.) - 1 Jul 2024

Kalim Ubaid Ullah, Biradar Rahul, Junttila Sini, Khan Mohd Moin, Tripathi Subhash, Khan Meraj Hasan, Smolander Johannes, Kanduri Kartiek, Envall Tapio, Laiho Asta, Marson Alexander, Rasool Omid, Elo Laura L, Lahesmaa Riitta

Abstract excerpt

Gene regulatory elements, such as enhancers, greatly influence cell identity by tuning the transcriptional activity of specific cell types. Dynamics of enhancer landscape during early human Th17 cell differentiation remains incompletely understood. Leveraging ATAC-seq-based profiling of chromatin accessibility and comprehensive analysis of key histone marks, we identified a repertoire of enhancers that...

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Autoimmune Diseases
Binding Sites
Cell Differentiation
CRISPR-Cas Systems
Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Nuclear Receptor Subfamily 1, Group F, Member 1

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Identifiers

PMID: 38788884
DOI: 10.1016/j.clim.2024.110261

Genes

RORA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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