Article

Multiple pathways of LRRK2-G2019S / Rab10 interaction in dopaminergic neurons

2020-09-28

Abstract excerpt

<h4>Background</h4> Inherited mutations in the LRRK2 protein are the most common known cause of Parkinson’s, but the mechanisms by which increased kinase activity of mutant LRRK2 leads to pathological events remain to be determined. In vitro assays (heterologous cell culture, phospho-protein mass spectrometry) suggest that several Rab proteins might be directly phosphorylated by LRRK2-G2019S . Which Rabs intera...

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Literature Corpus work: e402ffb3-650a-5309-9d64-83c22d416420
DOI: 10.1101/2020.09.28.316992

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