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Article

Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons.

Journal of Parkinson's disease - 1 Jan 2021

Fellgett Alison, Middleton C Adam, Munns Jack, Ugbode Chris, Jaciuch David, Wilson Laurence G, Chawla Sangeeta, Elliott Christopher J H

Abstract excerpt

BACKGROUND: Inherited mutations in the LRRK2 protein are common causes of Parkinson's disease, but the mechanisms by which increased kinase activity of mutant LRRK2 leads to pathological events remain to be determined. In vitro assays (heterologous cell culture, phospho-protein mass spectrometry) suggest that several Rab proteins might be directly phosphorylated by LRRK2-G2019S. An in vivo screen of Rab...

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Identifiers

PMID: 34250948
DOI: 10.3233/JPD-202421
PMCID: PMC8609683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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