Article

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson’s disease vulnerable dopamine axons

2025-08-28

Abstract excerpt

The end-stage pathology of Parkinson’s disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechanisms behind synaptic deficits is crucial for early therapeutic intervention, yet these remain largely unknown. In the SNc, different dopamine neuron subtypes show varying suscepti...

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Literature Corpus work: 8b0dac43-4bdf-5bcc-a54c-9c1c9e28f339
DOI: 10.1101/2025.08.28.672006

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