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Article

The synaptic function of LRRK2.

Biochemical Society transactions - 1 Oct 2012

Lee Seongsoo, Imai Yuzuru, Gehrke Stephan, Liu Song, Lu Bingwei

Abstract excerpt

Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most frequent genetic lesions so far found in familial as well as sporadic forms of PD (Parkinson's disease), a neurodegenerative disease characterized by the dysfunction and degeneration of dopaminergic and other neuronal types. The molecular and cellular mechanisms underlying LRRK2 action remain poorly defined. Synaptic dysfunction has been increasingly...

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Identifiers

PMID: 22988863
DOI: 10.1042/BST20120113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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