Article

Combined knockout of <i>Lrrk2</i> and <i>Rab29</i> does not result in behavioral abnormalities <i>in vivo</i>

2020-05-15

Abstract excerpt

Coding mutations in the LRRK2 gene, encoding for a large protein kinase, have been shown to cause familial Parkinson’s disease (PD). The immediate biological consequence of LRRK2 mutations is to increase kinase activity, leading to the suggestion that inhibition of this enzyme might be useful therapeutically to slow disease progression. Genome-wide association studies have identified the chromosomal loci around...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c4431b7-92e9-59d1-81d0-c75b0c2312df
DOI: 10.1101/2020.05.13.093708

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combined knockout of <i>Lrrk2</i> and <i>Rab29</i> does not result in behavioral abnormalities <i>in vivo</i>DOI 10.1101/2020.05.13.093708Read

Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo.Semantic proximity Read

LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis.Semantic proximity Read

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.Semantic proximity Read

A <i>Drosophila</i> model for <i>LRRK2</i> -linked parkinsonismSemantic proximity Read

Dopaminergic Neurodegeneration Induced by Parkinson’s Disease-Linked G2019S LRRK2 is Dependent on Kinase and GTPase ActivitySemantic proximity Read

LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.Semantic proximity Read

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.Semantic proximity Read

Multiple pathways of LRRK2-G2019S / Rab10 interaction in dopaminergic neuronsSemantic proximity Read

Modeling Parkinson’s disease in LRRK2 rodentsSemantic proximity Read

Behavioral Deficits and Striatal DA Signaling in LRRK2 p.G2019S Transgenic Rats: A Multimodal Investigation Including PET NeuroimagingSemantic proximity Read

Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.Semantic proximity Read

Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survivalSemantic proximity Read