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Article

Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.

Acta neuropathologica communications - 18 Dec 2023

Singh Vijay, Menard Marissa A, Serrano Geidy E, Beach Thomas G, Zhao Hien T, Riley-DiPaolo Alexis, Subrahmanian Nitya, LaVoie Matthew J, Volpicelli-Daley Laura A

Abstract excerpt

Autosomal dominant pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease (PD). The most common mutation, G2019S-LRRK2, increases the kinase activity of LRRK2 causing hyper-phosphorylation of its substrates. One of these substrates, Rab10, is phosphorylated at a conserved Thr73 residue (pRab10), and is one of the most abundant LRRK2 Rab GTPases expressed in various tissues. The...

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Identifiers

PMID: 38110990
DOI: 10.1186/s40478-023-01704-9
PMCID: PMC10726543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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