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Article

The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.

Stem cell reports - 13 Feb 2024

Mamais Adamantios, Sanyal Anwesha, Fajfer Austin, Zykoski Catherine G, Guldin Michael, Riley-DiPaolo Alexis, Subrahmanian Nitya, Gibbs Whitney, Lin Steven, LaVoie Matthew J

Abstract excerpt

Mutations in the LRRK2 gene cause familial Parkinson's disease presenting with pleomorphic neuropathology that can involve α-synuclein or tau accumulation. LRRK2 mutations are thought to converge upon a pathogenic increase in LRRK2 kinase activity. A subset of small RAB GTPases has been identified as LRRK2 substrates, with LRRK2-dependent phosphorylation resulting in RAB inactivation. We used CRISPR-Cas9 genome...

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Identifiers

PMID: 38307024
DOI: 10.1016/j.stemcr.2024.01.001
PMCID: PMC10874859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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