Article

The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neurons

2023-04-30

Abstract excerpt

Mutations in the LRRK2 gene cause familial Parkinson’s disease presenting with pleomorphic neuropathology that can involve α-synuclein or tau accumulation. LRRK2 mutations are thought to converge toward a pathogenic increase in LRRK2 kinase activity. A subset of small Rab GTPases have been identified as LRRK2 substrates, with LRRK2-dependent phosphorylation resulting in Rab inactivation. We used CRISPR/Cas9 genome...

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Literature Corpus work: b232b608-5100-513f-bc57-b3f4f5a92cd5
DOI: 10.1101/2023.04.30.538317

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