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Article

LRRK2 at the pre‐synaptic site: A 16‐years perspective

18 Nov 2020

Abstract excerpt

Parkinson's disease is a common neurodegenerative disorder and is clinically characterized by bradykinesia, rigidity, and resting tremor. Missense mutations in the leucine-rich repeat protein kinase-2 gene (LRRK2) are a recognized cause of inherited Parkinson's disease. The physiological and pathological impact of LRRK2 is still obscure, but accumulating evidence indicates that LRRK2 orchestrates diverse aspects...

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PMID: 33206398
DOI: 10.1111/jnc.15240

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