Article

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors

2023-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Gain-of-function mutations in the LRRK2 gene cause Parkinson’s disease (PD), characterized by debilitating motor and non-motor symptoms. Increased phosphorylation of a subset of RAB GTPases by LRRK2 is implicated in PD pathogenesis. We find that increased phosphorylation of RAB3A, a cardinal synaptic vesicle precursor (SVP) protein, disrupts anterograde axonal transport of SVPs in iPSC-derived...

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Literature Corpus work: d259656a-cd2b-5eff-8017-ebf10bade9a3
DOI: 10.1101/2023.07.25.550521

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