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Article

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.

Molecular neurodegeneration - 13 Feb 2018

Jeong Ga Ram, Jang Eun-Hae, Bae Jae Ryul, Jun Soyoung, Kang Ho Chul, Park Chi-Hu, Shin Joo-Ho, Yamamoto Yukio, Tanaka-Yamamoto Keiko, Dawson Valina L, Dawson Ted M, Hur Eun-Mi, Lee Byoung Dae

Abstract excerpt

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly defined. Given the increasing evidence suggesting a role of LRRK2 in membrane and vesicle trafficking, here we systemically screened Rab GTPases, core...

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Identifiers

PMID: 29439717
DOI: 10.1186/s13024-018-0240-1
PMCID: PMC5811984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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