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Article

In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3.

G3 (Bethesda, Md.) - 1 Jun 2020

Petridi Stavroula, Middleton C Adam, Ugbode Chris, Fellgett Alison, Covill Laura, Elliott Christopher J H

Abstract excerpt

LRRK2 mutations cause Parkinson's, but the molecular link from increased kinase activity to pathological neurodegeneration remains undetermined. Previous in vitro assays indicate that LRRK2 substrates include at least 8 Rab GTPases. We have now examined this hypothesis in vivo in a functional, electroretinogram screen, expressing each Rab with/without LRRK2-G2019S in selected Drosophila dopaminergic neurons. Our...

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PMID: 32321836
DOI: 10.1534/g3.120.401289
PMCID: PMC7263684

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