Article

Structural Insights into Specific Recognition of mononucleosome by the catalytic domain of Human KMT5A

2026-07-09

Abstract excerpt

<title>Abstract</title> <p>SET 8 is the methyltransferase responsible for histone H4 lysine 20 monomethylation (H4K20me1), essential for genomic stability and cell cycle progression. Here we report three cryo-EM structures of human SET 8 catalytic domain bound to canonical nucleosomes at 3.17 Å, 3.14 Å, and 3.10 Å resolutions, revealing distinct conformational states. SET 8 engages the nucleosome acidic patch via...

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Literature Corpus work: e3e5c135-9ffe-5b3c-8cab-a4f1a1f75afe
DOI: 10.21203/rs.3.rs-10286496/v1

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