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AI-empowered integrative structural characterization of m6A methyltransferase complex

10 Nov 2022

Abstract excerpt

N 6 -methyladenosine (m 6 A) is the most abundant and prevalent internal modification in mRNA. 1 In mammals, m 6 A exerts pivotal roles in posttranscriptional regulation and its dysregulation is implicated in various diseases including cancer. 2 m 6 A is installed by a multicomponent methyltransferase complex (MTC, also known as the m 6 A writer complex). 3 , 4 The mammalian MTC is composed of the core m 6 A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36357785
DOI: 10.1038/s41422-022-00741-8

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