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Article

SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.

The Journal of biological chemistry - 26 Aug 2005

Yin Yinliang, Liu Changdong, Tsai Sau Na, Zhou Bo, Ngai Sai Ming, Zhu Guang

Abstract excerpt

Methylation of lysine 20 in histone H4 has been proven to play important roles in chromatin structure and gene regulation. SET8 is one of the methyltransferases identified to be specific for this modification. In this study, the minimal active SET domain of SET8 has been mapped to the region of amino acids 195-352. This region completely retains the same methylation activity and substrate specificity as the...

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Identifiers

PMID: 15964846
DOI: 10.1074/jbc.M501691200

Genes

SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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