Article
SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties.
Nucleic acids research - 6 May 2022
Zakharova Vlada V, Magnitov Mikhail D, Del Maestro Laurence, Ulianov Sergey V, Glentis Alexandros, Uyanik Burhan, Williart Alice, Karpukhina Anna, Demidov Oleg, Joliot Veronique, Vassetzky Yegor S, Mège René-Marc, Piel Matthieu, Razin Sergey V, Ait-Si-Ali Slimane
Abstract excerpt
Imbalance in the finely orchestrated system of chromatin-modifying enzymes is a hallmark of many pathologies such as cancers, since causing the affection of the epigenome and transcriptional reprogramming. Here, we demonstrate that a loss-of-function mutation (LOF) of the major histone lysine methyltransferase SETDB1 possessing oncogenic activity in lung cancer cells leads to broad changes in the overall...
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