Article

Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase

2023-07-27

Abstract excerpt

Histone lysine methyltransferase of SUV420H1, which is responsible for site-specific di-/tri-methylation of histone H4 lysine 20 (H4K20), has crucial roles in DNA-templated processes, including DNA replication, DNA damage repair and chromatin compaction. Its mutations frequently occur in human cancers. Nucleosomes containing the histone variant H2A.Z enhance the catalytic activities of SUV420H1 in H4K20 di-methyla...

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Literature Corpus work: 8ed55249-d1f1-5cdf-9e50-9161e55d7de9
DOI: 10.1101/2023.07.27.549245

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