Article

Hierarchical Anchoring–Gating Dictates Specific H4K16 Acetylation by the Human MSL Complex

2026-03-04

Abstract excerpt

Histone acetylation is a versatile post-translational modification essential for diverse biological processes. While nearly all histone acetyltransferases (HATs) act promiscuously on multiple lysine residues, the human male-specific lethal (MSL) acetyltransferase complex mediates strictly site-specific acetylation of histone H4 at lysine 16 (H4K16ac), with its underlying mechanism remaining enigmatic. Here, we lev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99e77752-82f2-56a0-b8c1-5ba4fa9fa213
DOI: 10.64898/2026.03.03.709310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hierarchical Anchoring–Gating Dictates Specific H4K16 Acetylation by the Human MSL ComplexDOI 10.64898/2026.03.03.709310Read

KAT8 beyond Acetylation: A Survey of Its Epigenetic Regulation, Genetic Variability, and Implications for Human Health.Semantic proximity Read

PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1Semantic proximity Read

Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanismSemantic proximity Read

Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferaseSemantic proximity Read

Nucleosome context regulates chromatin reader preferenceSemantic proximity Read

Acidic patch histone mutations and their effects on nucleosome remodeling.Semantic proximity Read

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosomeSemantic proximity Read

Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylationSemantic proximity Read

Mechanistic insights into chromatin modulation by the “orphan” remodeler ATRXSemantic proximity Read

Structural determination of human nucleosomes reconstituted by the ExACT platformSemantic proximity Read

The biological functions of Naa10 – from amino-terminal acetylation to human diseaseSemantic proximity Read

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.Semantic proximity Read