Article

Structure of the human Bre1 complex bound to the nucleosome

2023-04-01

Abstract excerpt

<h4>Summary</h4> Histone H2B monoubiquitination (at Lys120 in humans) regulates transcription elongation and DNA repair. In humans, H2B monoubiquitination is catalyzed by the heterodimeric Bre1 complex composed of Bre1A/RNF20 and Bre1B/RNF40. The Bre1 proteins generally function as tumor suppressors, while in certain cancers, they facilitate cancer cell proliferation. To reveal the structural basis of H2BK120 ubi...

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Literature Corpus work: d6d14c49-91f1-5519-86ca-fe60fa43a777
DOI: 10.1101/2023.03.31.535082

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