Article

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome

2019-08-16

Abstract excerpt

<h4>SUMMARY</h4> Mixed Lineage Leukemia (MLL) family histone methyltransferases are the key enzymes that deposit histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. Despite extensive structural and biochemical studies, the molecular mechanism by which the MLL complexes recognize histone H3K4 within the nucleosome core particle (NCP) remains unclear. Here, we report the single-p...

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Literature Corpus work: 47d5bda7-fe69-552d-81cf-e5a605b30bdc
DOI: 10.1101/737478

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