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Article

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.

Nature communications - 5 Dec 2019

Park Sang Ho, Ayoub Alex, Lee Young-Tae, Xu Jing, Kim Hanseong, Zheng Wei, Zhang Biao, Sha Liang, An Sojin, Zhang Yang, Cianfrocco Michael A, Su Min, Dou Yali, Cho Uhn-Soo

Abstract excerpt

Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. Despite extensive structural and biochemical studies, the molecular mechanisms whereby the MLL complexes recognize histone H3K4 within nucleosome core particles (NCPs) remain unclear. Here we report the single-particle cryo-electron...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31804488
DOI: 10.1038/s41467-019-13550-2
PMCID: PMC6895043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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