Article

Somatic evolution in human blood and colon

2019-01-01

Abstract excerpt

All cancers were once normal cells. They became cancerous through the chance acquisition of particular somatic mutations that gave them a selective advantage over their neighbours. Thus, the mutations that initiate cancer occur in normal cells, and the normal clonal dynamics of the tissue determine a mutant cell's ability to establish a malignant clone; yet these remain poorly understood in humans. One tissue was...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3aff347-be31-58f2-b311-8a182e86d155
DOI: 10.17863/cam.37059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic evolution in human blood and colonDOI 10.17863/cam.37059Read

High-depth Whole Genome Sequencing of Single Human Colon Crypts Uncovers New View on Crypt ClonalitySemantic proximity Read

Population dynamics of normal human blood inferred from somatic mutations.Semantic proximity Read

The evolutionary dynamics and fitness landscape of clonal haematopoiesisSemantic proximity Read

Stem cells as common ancestors in a colorectal cancer ancestral tree.Semantic proximity Read

Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.Semantic proximity Read

Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon cryptsSemantic proximity Read

Clonal dynamics of haematopoiesis across the human lifespanSemantic proximity Read

Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.Semantic proximity Read

The evolutionary dynamics and fitness landscape of clonal hematopoiesis.Semantic proximity Read

A body map of somatic mutagenesis in morphologically normal human tissues.Semantic proximity Read

Clonal dynamics of haematopoiesis across the human lifespanSemantic proximity Read

Mutation count and mutation profile analyses of single-nucleotide variants in single human colon cryptsSemantic proximity Read