Article

High-depth Whole Genome Sequencing of Single Human Colon Crypts Uncovers New View on Crypt Clonality

2025-09-26

Abstract excerpt

<h4>SUMMARY</h4> It is generally accepted that each colon crypt is monoclonal and is populated by a single stem cell lineage after early human life. It has been impossible to profile somatic mutations genome-wide because high-depth and high-quality whole genome sequencing (WGS) of single cells is unachievable without tissue culture or whole genome amplification (WGA). Therefore, the cell-to-cell heterogeneity in...

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Literature Corpus work: 849e4723-898a-5df2-848d-f9267bf41a8d
DOI: 10.1101/2025.09.24.677335

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