Article
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Cell stem cell - 1 Jun 2018
Nicholson Anna M, Olpe Cora, Hoyle Alice, Thorsen Ann-Sofie, Rus Teja, Colombé Mathilde, Brunton-Sim Roxanne, Kemp Richard, Marks Kate, Quirke Phil, Malhotra Shalini, Ten Hoopen Rogier, Ibrahim Ashraf, Lindskog Cecilia, Myers Meagan B, Parsons Barbara, Tavaré Simon, Wilkinson Mark, Morrissey Edward, Winton Douglas J
Abstract excerpt
We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately seven active stem cells residing within each colonic crypt has to be mutated. Second, the mutated stem cell has to replace neighbors to populate the entire crypt in a process that takes...
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