Article

Mutation count and mutation profile analyses of single-nucleotide variants in single human colon crypts

2026-06-14

Abstract excerpt

Genetic heterogeneity due to the accumulation of mutations in normal tissues can increase cancer risk and be an important factor in many age-related degenerative and chronic diseases. Somatic mutations can arise from DNA damage or replication errors and accumulate in normal tissues with age. We obtained high depth whole genome sequencing data to comprehensively profile somatic mutations in 106 single human colon c...

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Literature Corpus work: b18009d0-359e-5585-ad8b-90f47ac86fde
DOI: 10.64898/2026.06.11.731472

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