Article

KRAS silencing alters chromatin physical organization and transcriptional activity in colorectal cancer cells

2024-04-16

Abstract excerpt

<title>Abstract</title> <p>Clinical data revealed that KRAS mutant tumors, while initially sensitive to treatment, rapidly bypass KRAS dependence to acquire a drug-tolerant phenotype. However, the mechanisms underlying the transition from a drug-sensitive to a drug-tolerant state still elude us. Here, we show that global chromatin reorganization is a recurrent and specific feature of KRAS-dependent cells that tol...

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Identifiers and source

Literature Corpus work: e356da7e-4787-5611-af53-126e079eeec6
DOI: 10.21203/rs.3.rs-3752760/v3

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