Article

Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal Cancer

2020-09-04

Abstract excerpt

<h4>ABSTRACT</h4> The extent and function of chromatin state aberrations during colorectal cancer (CRC) progression is not completely understood. Here, by comprehensive epigenomic characterization of 56 tumors, adenomas, and their matched normal tissues, we define the dynamics of chromatin states during the progression of colorectal cancer. H3K27ac-marked active enhancer state could distinguish between different...

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Literature Corpus work: 9dc9f82b-196b-5a8e-93e3-cc44a3caa69d
DOI: 10.1101/2020.09.04.283838

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