Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromatin Remodeling in Patient‐Derived Colorectal Cancer Models

21 Feb 2024

Abstract excerpt

Patient-Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient-derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear. Herein, the transcriptomic and chromatin accessibility landscapes of matched colorectal cancer (CRC) PDO, PDX, PDO-derived PDX (PDOX), and original patient tumors (PT) are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Genetic factors in colorectal cancer
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38380561
DOI: 10.1002/advs.202303379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromatin Remodeling in Patient‐Derived Colorectal Cancer ModelsPMID 38380561Read ↗

Chromatin Remodeling in Patient-Derived Colorectal Cancer ModelsSemantic proximity Read ↗

Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal CancerSemantic proximity Read ↗

Modeling colorectal cancer: A bio‐resource of 50 patient‐derived organoid linesSemantic proximity Read ↗

Dissection and reconstruction of the colorectal cancer tumor microenvironmentSemantic proximity Read ↗

Patient-derived organoids reflect the genetic profile of endometrial tumors and predict patient prognosisSemantic proximity Read ↗

Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilitiesSemantic proximity Read ↗

Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistanceSemantic proximity Read ↗

Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory Circuits During Response to MAPK Inhibition in BRAF-mutant Colorectal CancerSemantic proximity Read ↗

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.Semantic proximity Read ↗

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironmentSemantic proximity Read ↗

Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors.Semantic proximity Read ↗

Deciphering spatial heterogeneity of patient-derived organoids of colorectal tumors for drug discoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.