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Tracing the evolution of single-cell 3D genomes in Kras-driven cancers

18 Aug 2025

Abstract excerpt

Although three-dimensional (3D) genome structures are altered in cancer, it remains unclear how these changes evolve and diversify during cancer progression. Leveraging genome-wide chromatin tracing to visualize 3D genome folding directly in tissues, we generated 3D genome cancer atlases of oncogenic Kras-driven mouse lung adenocarcinoma (LUAD) and pancreatic ductal adenocarcinoma. Here we define nonmonotonic,...

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PMID: 40825871
DOI: 10.1038/s41588-025-02297-w

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