Article

Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis

2022-08-27

Abstract excerpt

Although 3D genome architecture can be essential for gene regulation, the biological implications of long-range chromatin interactions in disease remain elusive. In this study, we traced the early evolution and malignant transformation of colorectal cancer by generating high-resolution chromatin conformation maps of 33 colon samples spanning different stages of early neoplastic growth from polyps of Familial Adeno...

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Literature Corpus work: c7c5b86a-2f56-5c27-b482-a08283697cd0
DOI: 10.1101/2022.08.26.505505

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