Article

Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory Circuits During Response to MAPK Inhibition in BRAF-mutant Colorectal Cancer

2025-06-20

Abstract excerpt

<h4>Background</h4> Aberrant enhancer dynamics play a critical role in the initiation and progression of colorectal cancer (CRC). BRAF V600E -mutated metastatic CRC may be a unique subtype, exhibiting a strong epigenetic phenotype. Interestingly, bromodomain 2, a reader protein for H3K27ac-marked enhancers, was found to be synthetically lethal in CRC with BRAF + EGFR inhibition. <h4>Design</h4> We evaluated th...

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Literature Corpus work: 6c2d882b-4d0a-58af-a285-8b4d75b30b5b
DOI: 10.1101/2025.06.15.659716

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