Article

The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers

2023-11-17

Abstract excerpt

<h4>Background</h4> Lysine acetyltransferase 2A (KAT2A) plays a pivotal role in epigenetic gene regulation across various types of cancer. In colorectal cancer (CRC), upregulation of KAT2A is associated with a more aggressive phenotype. Our study aims to elucidate the molecular underpinnings of KAT2A dependency in CRC and assess the consequences of KAT2A depletion. <h4>Methods</h4> We conducted a comprehensiv...

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Literature Corpus work: bfe32e0d-1d8e-5c37-b24c-664a5409511f
DOI: 10.1101/2023.11.15.567034

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