Article

Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC

2025-08-05

Abstract excerpt

<h4>ABSTRACT</h4> KRAS is mutationally activated in 45-50% of colorectal cancer (CRC) cases, and while KRAS-targeted therapies have shown some clinical promise, upfront and acquired resistance limit their efficacy. To explore the acute response and mechanisms underlying KRAS inhibitor resistance, we used targeted exome sequencing and single-cell spatial transcriptomics to analyze patient-matched pre-treatment, on...

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Literature Corpus work: 11b2d700-ee19-5669-ad39-a176b8b4a16d
DOI: 10.1101/2025.08.05.668666

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