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Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriers

2026-08-06

Abstract excerpt

Normal tissues frequently harbor oncogenic mutations without progressing to cancer, but the cellular basis of this resistance remains poorly defined. We asked whether transformation requires selection of a rare, permissive state within normal-like cell populations. Dermal fibroblasts and mammary epithelial cells responded uniformly to combined HRAS-G12V expression and p53 disruption. Cellular barcoding revealed no...

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Literature Corpus work
d0b498a8-4c28-5ae4-8294-5e556440a422
DOI
10.64898/2026.08.05.743116
Open publication

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Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriersDOI 10.64898/2026.08.05.743116
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