Back to search

Article

Functional promoter polymorphisms govern the differential expression of HMG-CoA Reductase gene in rat models of essential hypertension

2019-04-19

Abstract excerpt

<h4>ABSTRACT</h4> 3-Hydroxy-3-methyl glutaryl-coenzyme A reductase ( Hmgcr ) encoding the rate-limiting enzyme in the cholesterol biosynthesis pathway is a candidate gene for essential hypertension (EH). However, the regulation of Hmgcr in rat models of hypertension (viz. Spontaneously Hypertensive Rats [SHR] and its normotensive control Wistar/Kyoto [WKY] strain) is unknown. Here, we show that Hmgcr transcript...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e347c490-8801-5209-b4e3-0443509d337a
DOI
10.1101/614669
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional promoter polymorphisms govern the differential expression of HMG-CoA Reductase gene in rat models of essential hypertensionDOI 10.1101/614669
An evolutionarily-conserved promoter allele governs HMG-CoA reductase expression in spontaneously hypertensive rat.Semantic proximity
Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension.Semantic proximity
High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Impedance of Cholesterol BiosynthesisSemantic proximity
High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis.Semantic proximity
The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?Semantic proximity
A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations.Semantic proximity
HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study.Semantic proximity
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.Semantic proximity
Metabolic Syndrome Induces Over Expression of the Human AT1R: A Haplotype-Dependent Effect With Implications on Cardio-Renal Function.Semantic proximity
Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.Semantic proximity
The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosisSemantic proximity
The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease.Semantic proximity
Select a neighboring publication to make it the new centre.