A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations.

doi:10.1016/j.brainres.2010.04.073

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Article

A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations.

Brain research - 16 Jul 2010

Keller Lina, Murphy Charlotte, Wang Hui-Xin, Fratiglioni Laura, Olin Maria, Gafvels Mats, Björkhem Ingemar, Graff Caroline, Meaney Steve

Abstract excerpt

Variations in genes associated with cholesterol homeostasis have been reported to modify the risk of developing Alzheimer disease (AD). To date there have been few investigations into variations in genes directly involved in cholesterol biosynthesis and AD. We investigated the influence of the -911C>A polymorphism (rs3761740) in the hydroxy-methyl-glutaryl CoA reductase (HMGCR) gene promoter on basal and...

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Identifiers

PMID: 20450896
DOI: 10.1016/j.brainres.2010.04.073

Genes

HMGCR
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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