Article

The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis

2024-12-03

Abstract excerpt

Elevated cholesterol poses cardiovascular risks. The glucocorticoid receptor (GR) harbors a still undefined role in cholesterol regulation. Here, we report that a coding single nucleotide polymorphism (SNP) in the gene encoding the GR, rs6190 , associated with increased cholesterol in women according to UK Biobank and All Of Us datasets. In SNP-genocopying mice, we found that the SNP enhanced hepatic GR activity...

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Literature Corpus work: 60a75419-39e2-549a-a57c-dbfda744b565
DOI: 10.1101/2024.11.27.625727

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