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Article

High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis.

BioMed research international - 1 Jan 2022

Das Keshob Chandra, Hossain Mohammad Uzzal, Moniruzzaman Md, Salimullah Md, Akhteruzzaman Sharif

Abstract excerpt

HMG-CoA reductase or HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) is a rate-limiting enzyme involved in cholesterol biosynthesis. HMGCR plays an important role in the possible occurrence of hypercholesterolemia leading to atherosclerosis and coronary heart disease. This enzyme is a major target for cholesterol-lowering drugs such as "statin" which blocks the synthesis of mevalonate, a precursor for...

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Identifiers

PMID: 35707384
DOI: 10.1155/2022/4558867
PMCID: PMC9192228

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