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Article

The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?

Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2012

Nabika Toru, Ohara Hiroki, Kato Norihiro, Isomura Minoru

Abstract excerpt

The stroke-prone spontaneously hypertensive rat (SHRSP) is a unique genetic model of severe hypertension and cerebral stroke. SHRSP, as well as the spontaneously hypertensive rat, the parental strain of SHRSP, has made a tremendous contribution to cardiovascular research. However, the genetic mechanisms underlying hypertension and stroke in these rats have not yet been clarified. Recent studies using whole-genome...

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PMID: 22399095
DOI: 10.1038/hr.2012.30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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